Remove the selected options :
-----------------------------
$('#mySelect2').val(null).trigger('change');
============================================
Completly remove the select2 initialization :
--------------------------------------------
$('#payment_method').html('').select2({data: [{id: '', text: ''}]});// Set the value, creating a new option if necessary
if ($('#mySelect2').find("option[value='" + data.id + "']").length) {
$('#mySelect2').val(data.id).trigger('change');
} else {
// Create a DOM Option and pre-select by default
var newOption = new Option(data.text, data.id, true, true);
// Append it to the select
$('#mySelect2').append(newOption).trigger('change');
} var data = {
id: 1,
text: 'Barn owl'
};
var newOption = new Option(data.text, data.id, false, false);
$('#mySelect2').append(newOption).trigger('change');$('#select2')
.select2()
.on('select2:open', () => {
$(".select2-results:not(:has(a))").append('<a href="#" style="padding: 6px;height: 20px;display: inline-table;">Create new item</a>');
})